ChemicalBook CAS DataBase List 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-

2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo- synthesis

7synthesis methods

Product Name:2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-
CAS Number:356783-31-8
Molecular formula:C5H2FN3O
Molecular Weight:139.09

356783-28-3 Synthesis

356783-28-3
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2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-

356783-31-8
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Yield:356783-31-8 93%

Reaction Conditions:

with water;sodium acetate in dimethyl sulfoxide at 5 - 45; for 4 h;Large scale;

Steps:

3.2
(2) At room temperature, add 1.38 kg of 3,6-difluoro-2-cyanopyrazine to 3.96 liters of DMSO, cool down to 5 in an ice-water bath, slowly add 8.2 kg of 18% sodium acetate aqueous solution, increase the temperature significantly, and control the reaction system The temperature T<10°C, the reaction liquid was a light yellow clear liquid, stirred for 1 hour and then heated to 45°C and stirred for 3 hours. After the reaction, the temperature was lowered to 5°C and concentrated sulfuric acid was added dropwise to adjust the pH=5, extracted with 15L of ethyl acetate three times, and concentrated to obtain 1.29 kg of brown powder 6-fluoro-3-hydroxy-2-cyanopyrazine (yield 93%)

References:

Lanzhou Kangyuxin Biological Technology Co., Ltd.;Zhang Qiaolan CN111471025, 2020, A Location in patent:Paragraph 0076

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1374986-06-7 Synthesis