ChemicalBook CAS DataBase List 6-BROMO-8-CYCLOPENTYL-5-METHYL-2-METHYLSULFANYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE

6-BROMO-8-CYCLOPENTYL-5-METHYL-2-METHYLSULFANYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE synthesis

9synthesis methods

Product Name:6-BROMO-8-CYCLOPENTYL-5-METHYL-2-METHYLSULFANYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
CAS Number:362656-25-5
Molecular formula:C14H16BrN3OS
Molecular Weight:354.27

362656-23-3 Synthesis

8-cyclopentyl-5-Methyl-2-(Methylthio)pyrido[2,3-d]pyriMidin-7(8H)-one

362656-23-3
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6-BROMO-8-CYCLOPENTYL-5-METHYL-2-METHYLSULFANYL-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE

362656-25-5
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Yield:362656-25-5 96%

Reaction Conditions:

with bromine in dichloromethane at 20; for 16 h;

Steps:

1.1f Step 1f: 6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one) (compound 107):

Compound 106 (4 g, 14.6 mmol) was dissolved in dichloromethane (100 mL) was slowly added bromine (1.47 mL) and the reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was washed with saturated sodium thiosulfate solution (15 ml), then with saturated sodium carbonate solution (20 ml) quenched. The organic layer was separated, the organic layer was washed with water and brine, dried over sodium sulfate and concentrated under reduced pressure, to give compound 6-bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (19.7 g, yield: 96%).

References:

CN105622638,2016,A Location in patent:Paragraph 0156; 0157

362656-11-9 Synthesis