Ethyl 1-(aminomethyl)cyclopropanecarboxylate hydrochloride synthesis

Yield:362703-20-6 97%

Reaction Conditions:

with hydrogen;platinum(IV) oxide in methanol; under 2585.81 Torr; for 2 h;

Steps:

17.a

A solution of 1-cyano-cyclopropanecarboxylic acid ethyl ester (1.0 g, 7.18 mmol), concentrated hydrochloric acid (1.5 mL), and platinum oxide (0.20 g) in methanol (50 mL) was pressurized with 50 psi of hydrogen for 2 hr. The heterogeneous mixture was filtered through Celite and concentrated to give the desired amine as a hydrochloride salt (1.26 g, 97%). MS found: (M+H)+=144

References:

US2004/72802,2004,A1 Location in patent:Page/Page column 45-46