ChemicalBook CAS DataBase List 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide

4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide synthesis

9synthesis methods

Product Name:4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide
CAS Number:364-62-5
Molecular formula:C14H22ClN3O2
Molecular Weight:299.8

7232-21-5
188 suppliers
$39.00/10g

4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide

364-62-5
269 suppliers
$5.00/25mg

Yield:364-62-5 65%

Reaction Conditions:

with sodium hydrogencarbonate in methanol;dichloromethane

Steps:

2.1 Synthesis of 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide (3):
4-amino-5 -chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride 1 (5.0 g,14.9 mmol) was taken in DCM:MeOH (30 mL, 9.5:0.5) in a 250 mL separating funnel. To it was added saturated NaHCO3 solution (50 mL). The extracted organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. This was finally dried under high vaccum which affored a white solid (2.9 g, 65%). This was then used in the next step without any further purification.

References:

RAO M, Surya WO2017/37566, 2017, A1 Location in patent:Paragraph 00169

FullText