1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)- synthesis

3synthesis methods

Product Name:1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-
CAS Number:364050-21-5
Molecular formula:C16H11N3O2
Molecular Weight:277.28

356560-90-2 Synthesis

2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone

356560-90-2
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1,2-Ethanedione, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-

364050-21-5
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$2625.00/1g

Yield:364050-21-5 86%

Reaction Conditions:

with aq. HBr in dimethyl sulfoxide;

Steps:

5 Preparation 5

Preparation 5 6-[2-(6-Methylpyridin-2-yl)-2-oxo-acetyl]quinoxaline A stirred suspension of 6-(2-[6-methylpyridin-2-yl]-acetyl)quinoxaline (1.65 g, 6.3 mmole) in dry DMSO (50 ml) was heated to 70-80° C. (forming a yellow solution) and treated dropwise with aq. HBr (48%, 6 ml). After 2 h the solution was cooled, poured over ice-water and brought to pH 10 with K₂CO₃. Extraction with EtOAc (3*), drying over Na₂SO₄, filtration and concentration to dryness in vacuo gave the title compound as a crimson oil (1.5 g, 86%). m/z [ESMS]: 278 [M+H]⁺.

References:

US2003/149277,2003,A1

108-48-5 Synthesis

108-48-5
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$9.90/190μL

364050-21-5
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$2625.00/1g

References

258503-93-4
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$44.00/100mg

364050-21-5
6 suppliers
$2625.00/1g

References