![](/CAS/GIF/365996-06-1.gif)
tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate synthesis
- Product Name:tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
- CAS Number:365996-06-1
- Molecular formula:C11H15BrN2O2S
- Molecular Weight:319.22
![tert-Butyl nitrite](/CAS/GIF/540-80-7.gif)
540-80-7
360 suppliers
$29.00/25 g
![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE](/CAS/GIF/365996-05-0.gif)
365996-05-0
154 suppliers
$54.00/1 / G
![tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate](/CAS/GIF/365996-06-1.gif)
365996-06-1
135 suppliers
$56.00/250mg
Yield: 44%
Reaction Conditions:
with copper(ll) bromide in dichloromethane at 0; for 3 h;
Steps:
29.3 tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
To a stuffing solution of tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate (2.0 g, 7.84 mmol) in DCM (30 mL) was added tert-butyl nitrite (1.24 g, 12 mmol) and CuBr2 (1.78 g, 8 mmol). The solution was stirred at 0 °C for 3h. Once LCMS showed the reaction to be complete, solvents were then evaporated and the residue was purified with column separation to afford desired product as white solid (1.1 g, yield: 44%);LCMS: 318.9/320.9 (M+1).
References:
EPIZYME, INC.;DUNCAN, Kenneth, W.;CHESWORTH, Richard;MUNCHHOF, Michael, John;SHAPIRO, Gideon WO2015/200677, 2015, A2 Location in patent:Paragraph 00647; 00648
![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE](/CAS/GIF/365996-05-0.gif)
365996-05-0
154 suppliers
$54.00/1 / G
![tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate](/CAS/GIF/365996-06-1.gif)
365996-06-1
135 suppliers
$56.00/250mg
![Cupric bromide](/CAS/GIF/7789-45-9.gif)
7789-45-9
357 suppliers
$6.00/25g
![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE](/CAS/GIF/365996-05-0.gif)
365996-05-0
154 suppliers
$54.00/1 / G
![tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate](/CAS/GIF/365996-06-1.gif)
365996-06-1
135 suppliers
$56.00/250mg
![N-(tert-Butoxycarbonyl)-4-piperidone](/CAS/GIF/79099-07-3.gif)
79099-07-3
543 suppliers
$5.00/5g
![tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate](/CAS/GIF/365996-06-1.gif)
365996-06-1
135 suppliers
$56.00/250mg
![3-BROMO-4-OXO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/188869-05-8.gif)
188869-05-8
153 suppliers
$8.00/1g
![tert-butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate](/CAS/GIF/365996-06-1.gif)
365996-06-1
135 suppliers
$56.00/250mg