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6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone synthesis
- Product Name:6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone
- CAS Number:36725-28-7
- Molecular formula:C11H13N3O
- Molecular Weight:203.24
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120757-13-3
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![6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone](/CAS/GIF/36725-28-7.gif)
36725-28-7
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Yield:36725-28-7 65%
Reaction Conditions:
with hydrazine hydrate at 80; for 18 h;
Steps:
6-(4-aminophenyl)-5-methyl-4, 5-dihydropyridazin-3(2H )-one
To a solution of Intermediate 3, 2.69 g (11.04 minol), in ethanol, 70 mL, was added hydrazine hydrate, 1.40 mL (28.7 minol), the reaction was heated at 8000 for 18 hours. The reaction wasconcentrated under vacuum and triturated with ethyl acetate to give the desired product Intermediate 7, 1.46 g (65%).1H NMR (300 MHz, CD3OD): 6 [ppm] = 1.13 (d, 3H), 2.33 (d, IH), 2.66 (dd, IH), 3.28-3.40 (m, IH), 6.68 (d, 2H), 7.56 (d, 2H).UPLC-MS (Method 3): R = 0.47 min., 100%. MS (ESIpos): m/z (M÷H) 204.
References:
WO2018/86703,2018,A1 Location in patent:Page/Page column 204
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36725-28-7
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81937-39-5
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36725-28-7
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36725-28-7
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120757-16-6
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![6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone](/CAS/GIF/36725-28-7.gif)
36725-28-7
202 suppliers
$5.00/100mg