3-amino-N-(4-chlorophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide synthesis

1synthesis methods

Product Name:3-amino-N-(4-chlorophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide
CAS Number:371222-56-9
Molecular formula:C18H17ClN4OS
Molecular Weight:372.87

N-(4-chlorophenyl)-2-[(3-cyano-6-methyl-5,6,7,8-tetrahydro[1,6]naphthyridin-2-yl)sulfanyl]acetamide

371128-14-2
2 suppliers
inquiry

3-amino-N-(4-chlorophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

371222-56-9
2 suppliers
inquiry

Yield:371222-56-9 67%

Reaction Conditions:

with sodium ethanolate in ethanol; for 0.333333 h;Heating;Thorpe-Ziegler cyclisation;

References:

Abdel-Wadood, Fatma K.;Abdel-Monem, Maisa I.;Fahmy, Atiat M.;Geies, Ahmed A. [Journal of Chemical Research,2008,# 2,p. 89 - 94] Location in patent:experimental part