ChemicalBook CAS DataBase List IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester

IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester synthesis

7synthesis methods

Product Name:IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester
CAS Number:372198-69-1
Molecular formula:C10H9BrN2O2
Molecular Weight:269.09

N'-(5-bromo-2-pyridinyl)-N,N-dimethylimidoformamide

138240-34-3
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105-36-2 Synthesis

105-36-2
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$5.00/5 g

IMidazo[1,2-a]pyridine-3-carboxylic acid, 6-broMo-, ethyl ester

372198-69-1
111 suppliers
$14.00/250mg

Yield: 56%

Reaction Conditions:

with sodium hydrogencarbonate in isopropyl alcohol at 80;

Steps:

Ethyl 6-bromoimidazo [1,2-a] pyridine-3-carboxylate
Combine (E) -N '-(5-bromopyridin-2-yl) -N, N-dimethylformamidine (17.0 g, 74.53 mmol), sodium bicarbonate (12.5 g, 149.06 mmol) and Ethyl bromoacetate (37.3 g, 223.60 mmol) was added sequentially with isopropanol (200 mL). The reaction was stirred overnight at 80 degrees. LCMS showed the reaction was complete. The reaction solution was evaporated to dryness, and the residue was diluted with ethyl acetate and washed with water. The organic phase was dried over anhydrous sodium sulfate and concentrated to obtain crude product. The obtained crude product was beaten with isopropanol to obtain a pink solid compound (11.2 g, yield 56%).

References:

Shanghai Yinuo Pharmaceutical Co., Ltd.;Jiang Lei;Feng Zhiyong;Shang Ke;Shou Jianyong;Wu Danyi;Xu Yuan;Zhang Shuyun;Zhang Yi;Zhang Yuxing CN111039946, 2020, A Location in patent:Paragraph 0151-0152; 0157-0161

1072-97-5 Synthesis