4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER synthesis

7synthesis methods

Product Name:4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER
CAS Number:3751-82-4
Molecular formula:C10H15NO5
Molecular Weight:229.23

999-30-4
11 suppliers
$354.00/1g

140-88-5
516 suppliers
$12.00/100ml

4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER

3751-82-4
25 suppliers
$287.10/250mg

Yield:3751-82-4 702.5 g

Reaction Conditions:

with sodium ethanolate in toluene at 60; for 3 h;

Steps:

2.2

2.Add ethoxycarbonylglycine ethyl ester (VI) to the reaction flaskToluene solution,Add 560 g of toluene, 378 g of ethyl acrylate, and 306.2 g of sodium ethoxide.Raise the temperature to 60oC, maintain the temperature for 3 hours, monitor the reaction to completion, and lower the temperature to room temperature.Add acetic acid dropwise, stir for 15 minutes, add 2500 g of water, separate the layers, extract the aqueous phase twice with 1300 g of toluene, combine the organic phases, dry and obtain4-oxopyrrolidine-1,3-dicarboxylic acid diethyl ester(IV) 702.5 g, yield 85.3% in two steps.

References:

CN110746334,2020,A Location in patent:Paragraph 0040; 0041