2-O,3-O,5-O-Tribenzyl-β-D-ribofuranosylformaldehyde synthesis

Yield:37699-02-8 100%

Reaction Conditions:

Stage #1: methyl 2,3,5-tri-O-benzyl-β-D-ribofuranosyl carboxylatewith diisobutylaluminium hydride in toluene at -70; for 0.75 h;Inert atmosphere;
Stage #2: with methanol in toluene at -70 - 20;

References:

Araki, Lisa;Morita, Keiji;Yamaguchi, Maho;Zhao, Zheng-Yun;Wilson, Timothy J.;Lilley, David M. J.;Harusawa, Shinya [Journal of Organic Chemistry,2009,vol. 74,# 6,p. 2350 - 2356] Location in patent:supporting information; experimental part