(2E)-3-(3-chlorophenyl)-1-(2,5-dimethoxyphenyl)prop-2-en-1-one synthesis

Yield:38169-49-2 52%

Reaction Conditions:

with sodium hydroxide in ethanol;lithium hydroxide monohydrate at 20; for 2 h;Claisen-Schmidt Condensation;

Steps:

Procedure for the synthesis of the intermediate 1b

General procedure: 2,4-Dichlorobenzaldehyde (1.56 g, 8.9 mmol) was dissolvedin 10 mL ethanol, then 1 mL of 10% NaOH aqueoussolutionand2-methoxy-5-chloroacetophenone(1.5 g,8.1 mmol) were added into the reaction system in sequence.The reaction process was monitored by thin-layer chromatography(TLC). Stirred for 2 h at room temperature later,the precipitate was filtered, washed with 10 mL ethanol, anddried. 2.5 g of white powder 1b was obtained with a yield of91%,

References:

Cheng, Ning Ning;Zhang, Le Hua;Ge, Rui;Feng, Xiu E.;Li, Qing Shan [Medicinal Chemistry Research,2022,vol. 31,# 9,p. 1517 - 1544]