2-Chloro-6-methyl-3-pyridinecarboxylic acid ethyl ester synthesis

Yield:39073-14-8 73%

Reaction Conditions:

with oxalyl dichloride for 8 h;Reflux;

Steps:

1.1 1) Preparation of 6-methyl-2-chloronicotinic acid ethyl ester

45.25 g (0.25 mol) of 6-methyl-2-hydroxy-nicotinic acid ethyl ester was placed in a 1000 mL single-necked flask,To this was added 200 mL of oxalyl chloride,Heating up to reflux,Reaction 8h,After the reaction was monitored by TLC, the solvent was removed under reduced pressure, and the residue was poured into water. The solid was precipitated, the filtrate was filtered and the filter cake was washed with water and dried in air to obtain 36 g of a yellowish solid. Yield: 73%.

References:

CN106316931,2017,A Location in patent:Paragraph 0223; 0224; 0225