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ChemicalBook CAS DataBase List 2-(7-Fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid
393509-22-3

2-(7-Fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid synthesis

7synthesis methods
20826-94-2 Synthesis
Ethyl 2-oxocyclopentylacetate

20826-94-2
167 suppliers
$26.00/1g

61272-76-2 Synthesis
4-Fluoro-2-iodoaniline

61272-76-2
186 suppliers
$9.00/5g

2-(7-Fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

393509-22-3
6 suppliers
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Yield:-

Steps:

11.1 (+/-) 2-(7-fluoro-1,2,3-trihydrocyclopenta[2,3-b]indol-3-yl)acetic acid
Step 1 (+/-) 2-(7-fluoro-1,2,3-trihydrocyclopenta[2,3-b]indol-3-yl)acetic acid The ethyl ester of the title compound was prepared from 10.00 g of 4-fluoro-2-iodophenylamine and 6.57 g of ethyl 2-(2-oxocyclopentyl)acetate according to example 1, step 2, to yield 5.36 g of a yellow solid. 1H NMR (acetone-d6) δ9.76 (1H, br s), 7.34 (1H, dd), 7.03 (1H, d), 6.78 (1H, td), 4.14 (2H, q), 3.57 (1H, m), 2.85-2.55 (5H, m), 2.15 (1H, m), 1.22 (3H, t).

References:

Merck Frosst Canada & Co. US6410583, 2002, B1