ChemicalBook CAS DataBase List 1H-Pyrrole-2,5-dione, 3-[3-[(2,3-dihydroxypropyl)amino]phenyl]-4-(5-fluoro-1-methyl-1H-indol-3-yl)-

1H-Pyrrole-2,5-dione, 3-[3-[(2,3-dihydroxypropyl)amino]phenyl]-4-(5-fluoro-1-methyl-1H-indol-3-yl)- synthesis

1synthesis methods

Product Name:1H-Pyrrole-2,5-dione, 3-[3-[(2,3-dihydroxypropyl)amino]phenyl]-4-(5-fluoro-1-methyl-1H-indol-3-yl)-
CAS Number:396091-16-0
Molecular formula:C22H20FN3O4
Molecular Weight:409.41

1H-Pyrrole-2,5-dione, 3-[3-[[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]amino]phenyl]-4-(5-fluoro-1-methyl-1H-indol-3-yl)-

1222370-69-5
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1H-Pyrrole-2,5-dione, 3-[3-[(2,3-dihydroxypropyl)amino]phenyl]-4-(5-fluoro-1-methyl-1H-indol-3-yl)-

396091-16-0
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Yield:396091-16-0 66%

Reaction Conditions:

with methanol;toluene-4-sulfonic acid at 50; for 18 h;

References:

Gong, Leyi;Hirschfeld, Don;Tan, Yun-Chou;Heather Hogg;Peltz, Gary;Avnur, Zafrira;Dunten, Pete [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 5,p. 1693 - 1696] Location in patent:scheme or table