ChemicalBook CAS DataBase List 3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE synthesis

7synthesis methods

Product Name:3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE
CAS Number:36822-08-9
Molecular formula:C10H6N2OS
Molecular Weight:202.23

34761-09-6 Synthesis

3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER

34761-09-6
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$20.00/250mg

3473-63-0 Synthesis

3473-63-0
484 suppliers
$5.00/25g

3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE

36822-08-9
34 suppliers
$41.00/100mg

Yield:36822-08-9 94.1%

Reaction Conditions:

in 2-methoxy-ethanol at 150;Inert atmosphere;

Steps:

2.2 Step 2: Synthesis of benzo[4,5]thiophene[3,2-d]pyrimidin-4(3H)-one

Dissolve 3-aminobenzothiophene-2-carboxylic acid ethyl ester (5g, 23mmol), and formamidine acetate (7.2g, 69mmol) in 23mL of ethylene glycol methyl ether,The reaction system was evacuated to change nitrogen, heated to 150°C and refluxed overnight,After TLC detects that the reaction is complete, the system is cooled to room temperature, the product is precipitated, filtered, and the product is washed with ethanol until the filtrate is colorless.The solid was collected and dried to obtain an off-white granular solid benzo[4,5]thiophene[3,2-d]pyrimidin-4(3H)-one (4.38g, 94.1%).

References:

CN111440216,2020,A Location in patent:Paragraph 0141; 0145-0147

34761-09-6 Synthesis

34761-09-6
63 suppliers
$20.00/250mg