3METHYL4NITROBIPHENYL synthesis
- Product Name:3METHYL4NITROBIPHENYL
- CAS Number:69314-47-2
- Molecular formula:C13H11NO2
- Molecular Weight:213.23
Yield:69314-47-2 90 %
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in 1,4-dioxane;water at 100;
Steps:
1.2 Step two:
In the compound 4-chloro-2-methyl-1-nitrobenzeneAfter ((2.57g, 15mmol) was dissolved in 1,4-dioxane (130mL),An aqueous solution of phenylboronic acid (1.83 g, 15 mmol), Pd(PPh3)4 (0.18 g, 0.15 mmol) and K2CO3 (12.8 g, 93 mmol) was added thereto, and the resultant was stirred at 100° C. for 6 hours.After the reaction was terminated, the resultant was cooled to room temperature, and extracted with distilled water and ethyl acetate.The organic layer was dried over MgSO4, and then filtered and concentrated.Using ethyl acetate and hexane as a developing solvent, the concentrated residue was purified by column chromatography to obtain the target compound 3-methyl-4-nitro-1,1'-biphenyl (2.88g, yield 90% ).
References:
CN115417845,2022,A Location in patent:Paragraph 0033; 0034
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