4-(1,3-BENZOTHIAZOL-2-YLMETHYL)ANILINE synthesis
- Product Name:4-(1,3-BENZOTHIAZOL-2-YLMETHYL)ANILINE
- CAS Number:37859-28-2
- Molecular formula:C14H12N2S
- Molecular Weight:240.32
95-16-9
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$14.14/10gm:
106-49-0
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37859-28-2
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$168.00/250mg
Yield:37859-28-2 81%
Reaction Conditions:
with N,N,N-tributyl-1-butanaminium iodide;1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) at 40; for 10 h;
Steps:
19 Example 19 Synthesis of derivative Is (n=1, (R)n=4-amino)
Weigh 2H- Benzothiazole (0.3 mmol, 40.6 mg), p-toluidine (13.0 mmol, 1391 mg), Selectfluor (1.5 mmol, 531.0 mg) and tetrabutylammonium iodide (0.135 mmol, 49.8 mg) were reacted in 15 mL In the tube, the reaction was stirred under a sand bath at 40°C, monitored by TLC, and the reaction was completed after about 10 h, the reaction solution was concentrated to remove the solvent, and the concentrated solution was separated by column chromatography (the eluent was the petroleum ether- ethyl acetate mixed solvent) to obtain 58.30 mg of white solid, namely derivative Is; yield 81%;
References:
CN114163399,2022,A Location in patent:Paragraph 0033
1197-55-3
393 suppliers
$13.00/25g
137-07-5
289 suppliers
$10.00/5g
37859-28-2
13 suppliers
$168.00/250mg
150-13-0
886 suppliers
$5.00/25g
137-07-5
289 suppliers
$10.00/5g
37859-28-2
13 suppliers
$168.00/250mg