4-(1,3-benzoxazol-2-yl)benzenol synthesis

13synthesis methods

Product Name:4-(1,3-benzoxazol-2-yl)benzenol
CAS Number:3315-19-3
Molecular formula:C13H9NO2
Molecular Weight:211.22

95-55-6 Synthesis

95-55-6
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99-96-7 Synthesis

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3315-19-3
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Yield:3315-19-3 99%

Reaction Conditions:

boric acid in 1,2-dichloro-benzene; for 18 h;Heating / reflux;

Steps:

1.a

A 250 mi three necked reaction flask, equipped with a reflux condenser combined with a water separator and an oil bath with a magnetic stirrer was charged with 16.4g (150mmol) of 2-aminophenol (Fluka), 20.8g (150 mmol) of 4-hydroxy-benzoic acid and 1.2g of boric acid in 150 mi of 1, 2-dichlorobenzene. After 18 hours of reflux 5 ml of water were separated. On tic (hexane/ethylacetate = 3: 2) no starting material could be observed. The reaction mixture was cooled and diluted with hexane. Crystals were formed, which were filtered off, washed with hexane and dried at 60°C in a vacuum to yield 31.3g (99%) of the product. M. p. 242-245°C. UV (ethanol) 306 nm (31'831).

References:

WO2005/53631,2005,A1 Location in patent:Page/Page column 26

123-08-0 Synthesis