4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzenamine synthesis

Yield: 90%

Reaction Conditions:

with hydrogen;palladium on activated charcoal in ethanol;dichloromethane under 1551.44 Torr; for 1 h;

References:

Hu, Baihua;Ellingboe, John;Han, Stella;Largis, Elwood;Lim, Kitae;Malamas, Michael;Mulvey, Ruth;Niu, Chuansheng;Oliphant, Alexander;Pelletier, Jeffrey;Singanallore, Thiruvikraman;Sum, Fuk-Wah;Tillett, Jeff;Wong, Victoria [Bioorganic and Medicinal Chemistry,2001,vol. 9,# 8,p. 2045 - 2059]