![](/CAS/GIF/389602-90-8.gif)
4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE synthesis
- Product Name:4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE
- CAS Number:389602-90-8
- Molecular formula:C14H19NO2
- Molecular Weight:233.31
![Carbamic acid, N-[4-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)phenyl]-, phenylmethyl ester](/CAS/20210305/GIF/959939-45-8.gif)
959939-45-8
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![4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE](/CAS/GIF/389602-90-8.gif)
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Yield:389602-90-8 90%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in tetrahydrofuran at 20; for 16 h;
Steps:
37.ii
ii) 4-(l,4-dioxaspiro[4.51dec-8-vDaniline; Palladium (10 wt. %) on carbon (1.0 g) was added in one portion to a solution of benzyl N- [4-(l,4-dioxaspiro[4.5]dec-7-en-8-yl)phenyl]carbamate (7.01 g, 19.20 mmol) in THF (500 mL) and the reaction mixture was stirred under a hydrogen atmosphere at ambient temperature for 16 h. The reaction mixture was filtered and concentrated in vacuo to leave the title compound as a white solid (4.03 g, 90%). 1H NMR δ 1.51 - 1.76 (m, 8H), 2.32 - 2.43 (m, IH), 3.87 (s, 4H), 4.77 (s, 2H), 6.48 (d, 2H), 6.86 (d, 2H).
References:
WO2007/141517,2007,A1 Location in patent:Page/Page column 78
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56309-94-5
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$34.79/5g
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![1,4-DIOXA-SPIRO[4,5]DEC-7-EN-8-BORONIC ACID, PINACOL ESTER](/CAS/GIF/680596-79-6.gif)
680596-79-6
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$7.00/100mg
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![benzyl 4-bromophenylcarbamate](/CAS2/GIF/92159-87-0.gif)
92159-87-0
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$49.50/5g
![4-(1,4-DIOXASPIRO[4,5]DEC-8-YL) BENZENAMINE](/CAS/GIF/389602-90-8.gif)
389602-90-8
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