4-(1-methyl-1H-pyrazol-4-yl)benzoic acid synthesis
- Product Name:4-(1-methyl-1H-pyrazol-4-yl)benzoic acid
- CAS Number:199678-06-3
- Molecular formula:C11H10N2O2
- Molecular Weight:202.21
1339768-73-8
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199678-06-3
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Yield:199678-06-3 71.3%
Reaction Conditions:
with methanol;water;sodium hydroxide at 20; for 16 h;
Steps:
Into a 20-mL vial, was placed a solution of methyl 4-(1-methylpyrazol-4-yl)benzoate (P-1, 300.0 mg, 1.39 mmol, 1.00 equiv) in MeOH (10 mL), a solution of sodium hydroxide (221.96 mg, 5.549 mmol, 4.00 equiv) in H2O (5 mL). The resulting solution was stirred for 16h at room temperature. The resulting mixture was concentrated under vacuum.2M HCl was added to adjust the pH to 2-3. The solids were collected by filtration. This resulted in 200 mg (71.3%) of 4-(1-methylpyrazol-4-yl)benzoic acid (Acid P) as a white solid.
References:
WO2021/127166,2021,A1 Location in patent:Paragraph 00100; 00103
15803-02-8
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14047-29-1
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199678-06-3
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37921-11-2
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199678-06-3
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619-42-1
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199678-06-3
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$60.00/100mg