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116290-73-4

4-(1-PIPERAZINYL)BENZAMIDE synthesis

2synthesis methods
-

Yield:116290-73-4 82%

Reaction Conditions:

in water at 100;

Steps:

1

Compound 6 (1.40 g, 10.0 mmol) and Compound 7 (4.6 g, 53.1 mmol) were added to water (10 mL) and stirred at 100 ° C overnight. After completion of the reaction, the mixture was cooled to room temperature, and a solid was precipitated, filtered, washed with water, toluene, and dried to give Compound 8 (1.68 g, 82%).

References:

CN108570039,2018,A Location in patent:Paragraph 0123