4-(1-PYRAZOLYL)-2-BUTANONE synthesis
- Product Name:4-(1-PYRAZOLYL)-2-BUTANONE
- CAS Number:89943-03-3
- Molecular formula:C7H10N2O
- Molecular Weight:138.17
288-13-1
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67-68-5
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67-64-1
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89943-03-3
16 suppliers
$106.00/250mg
Yield:89943-03-3 97%
Reaction Conditions:
with ruthenium trichloride;1,10-Phenanthroline;sodium carbonate;Selectfluor at 120; for 1 h;
Steps:
5
In a 50 ml round bottom flask,0.0581 g (1.0 mmol) of acetone was added,0.0075 g (1.1 mmol) of imidazole,0.0172 g (0.1 mmol) of ruthenium trichloride,0.0198 g of 1,10-phenanthroline (0.1 mmol) 0.7080 g (2.0 mmol) of selectfluor 0.2160 g (2.0 mmol) of sodium carbonate,5.0 ml of dimethylsulfoxide (DMSO), heated to 120 ° (: reflux for 1 hour to complete reaction with acetone (TLC). The reaction mixture was poured into 20 ml of water and extracted with ethyl acetate (10 ml X 3). The organic phases were combined and dried over anhydrous sodium sulfate.The solvent was evaporated and the residue was chromatographed on silica gel (eluent: petroleum ether / ethyl acetate = 7/1) to give 0.2518 g of a white solid , The yield was 97%.
References:
CN106699662,2017,A Location in patent:Paragraph 0035-0037
288-13-1
410 suppliers
$10.00/1g
78-94-4
4 suppliers
$35.79/25ml
89943-03-3
16 suppliers
$106.00/250mg