4-(1H-BENZIMIDAZOL-1-YL)ANILINE synthesis
- Product Name:4-(1H-BENZIMIDAZOL-1-YL)ANILINE
- CAS Number:52708-36-8
- Molecular formula:C13H11N3
- Molecular Weight:209.25
22492-14-4
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52708-36-8
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Yield:52708-36-8 89%
Reaction Conditions:
with palladium on activated charcoal;hydrazine hydrate monohydrate in ethanol at 80; for 13 h;Inert atmosphere;Solvent;
Steps:
1.2
2) Add to the 100ml three-necked flask3.0g N-(4-nitrophenyl)benzimidazole,0.31g Pd/C,10ml hydrazine hydrate,60ml ethanol,Reflux at 80°C for 13h in N2 atmosphere;After the reaction is completed,filter while hot;Take the filtrate, rotary steam;Use ethyl acetate-petroleum ether (1:1, v/v) eluent to pass through silica gel chromatography column,get red oily liquid productN-(4-Aminophenyl)benzimidazole,Yield 89%;
References:
CN114133380,2022,A Location in patent:Paragraph 0021; 0043; 0048-0050
51-17-2
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350-46-9
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52708-36-8
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$220.00/1g