ChemicalBook CAS DataBase List 4-(1H-BENZIMIDAZOL-2-YLTHIO)ANILINE

4-(1H-BENZIMIDAZOL-2-YLTHIO)ANILINE synthesis

3synthesis methods

Product Name:4-(1H-BENZIMIDAZOL-2-YLTHIO)ANILINE
CAS Number:956-13-8
Molecular formula:C13H11N3S
Molecular Weight:241.31

106-47-8 Synthesis

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Yield:956-13-8 85%

Reaction Conditions:

with triethylamine in ethanol; for 5.66667 h;Reflux;

Steps:

2.4 General Procedure for the C-S CouplingReaction Catalyzed by CuMTPOF

General procedure: The catalytic activity of CuMTPOF was tested for one ofthe important reactions i.e., C-S coupling. The C-S couplingreaction is generally carried out using homogeneous catalysts. However, their applications were confined dueto the separation and recycling of the steeply-priced Cucatalystsfrom the reaction mixture. Here MTPOF basedheterogeneous Cu is utilized as a catalyst for performingthe C-S coupling reaction. In this reaction a mixture of substitutedaryl halide (0.5 mmol), 2-mercaptobenzimidazole(0.5 mmol), CuMTPOF (0.05 g) and Et3N(3 eq,) in ethanol(10 mL), was refluxed for 2 h. After completion of thereaction, the catalyst was separated by centrifugation andwashed several times with ethanol, afterward filtrate wasadded to ice-cold water. The solid obtained was filtered anddried under vacuum. The crude products were purified bycolumn chromatography and characterized by NMR spectroscopy(see Supplementary information).

References:

Dani, Shilpa H.;Pratap, Umesh R. [Catalysis Letters,2022]

1H-Benzimidazole, 2-[(4-nitrophenyl)thio]-

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956-13-8
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References

134469-07-1
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956-13-8
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References