ChemicalBook CAS DataBase List [4-(1H-Pyrazol-1-yl)phenyl]acetic acid

[4-(1H-Pyrazol-1-yl)phenyl]acetic acid synthesis

6synthesis methods

Product Name:[4-(1H-Pyrazol-1-yl)phenyl]acetic acid
CAS Number:65476-24-6
Molecular formula:C11H10N2O2
Molecular Weight:202.21

143426-55-5 Synthesis

143426-55-5
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65476-24-6
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Yield:65476-24-6 800 mg

Reaction Conditions:

with hydrogenchloride;lithium hydroxide monohydrate at 110; for 1 h;

Steps:

2

2. A mixture of 1 (1.2 g, 6.55 mmol) and cone. HC1 (8 mL) was stirred at 110 °C for 1 h. The mix- ture was concentrated, the resulting solid material collected by filtration and washed with water to afford Intermediate 5 (800 mg) as a yellow solid.

References:

WO2022/147210,2022,A1 Location in patent:Page/Page column 34