4(1H)-Pyrimidinone, 2-cyclopropyl-6-methyl- (9CI) synthesis
- Product Name:4(1H)-Pyrimidinone, 2-cyclopropyl-6-methyl- (9CI)
- CAS Number:7043-10-9
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
Yield:7043-10-9 70%
Reaction Conditions:
with potassium carbonate in water at 20; for 0.25 h;Microwave irradiation;
Steps:
Ultrasound-Promoted Synthesis of 4-Pyrimidinols 3; General Procedure 1
General procedure: The corresponding amidine hydrochloride (2.54 mmol) and powdered K2CO3 (5.76 mmol) were dissolved in water (5.0 mL) in a 20-mL vessel. The β-keto ester (2.31 mmol) was added and the resulting mixture was irradiated for 5-15 min (see Table 2). Upon the end of the reaction (TLC, hexanes/EtOAc, 5:1), the mixture was diluted with sat. aq NH4Cl (5.0 mL) and extracted with CH2Cl2 (3 × 15 mL). The combined organic phases were dried (anhyd Na2SO4) and filtered. The filtrate was rotary evaporated and the obtained crude product was purified by column chromatography [silica gel, hexane/EtOAc mixtures or recrystallized (EtOH)].
References:
Vidal, Matías;García-Arriagada, Macarena;Rezende, Marcos Caroli;Domínguez, Moisés [Synthesis,2016,vol. 48,# 23,art. no. SS-2016-M0433-OP,p. 4246 - 4252]
