ChemicalBook CAS DataBase List 4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2-one

4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2-one synthesis

14synthesis methods

Product Name:4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2-one
CAS Number:13720-12-2
Molecular formula:C13H22O
Molecular Weight:194.31

2,2-DIMETHYL-6-OXOCYCLOHEXANECARBOXYLIC ACID METHYL ESTER

71135-95-0
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4-(2,2-dimethyl-6-methylenecyclohexyl)butan-2-one

13720-12-2
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Yield:-

Steps:

Multi-step reaction with 11 steps
2: 56 percent / LiI*2H₂O, 2,4,6-collidine / 19 h / Heating
3: 1.) O₃; 2.) NaBH₄ / methanol; 1.) -50 deg C, 0.25 h; 2.) -30 deg C, 1 h
4: pyridine / 18 h / Ambient temperature
5: 81 percent / CrO₃ / pyridine; CH₂Cl₂ / 1.5 h / Ambient temperature
6: 1.) 1.6 M n-BuLi / 1.) Et₂O, room temp., 3 h; 2.) THF, reflux, 4 h
7: 71 percent / Na, liq. NH₃ / tetrahydrofuran / 0.5 h
8: 75 percent / pyridine / 48 h / -20 °C
9: 90 percent / dibenzo-18-crown-6 / acetonitrile / a) room temp., 1 h; b) reflux, 18 h
10: 85 percent / 25 N NaOH / ethanol / 18 h / Heating
11: 77 percent / hexane; tetrahydrofuran / 2 h / 0 °C

References:

Magatti, Charles V.;Kaminski, James J.;Rothberg, Irvin [Journal of Organic Chemistry,1991,vol. 56,# 9,p. 3102 - 3108]

(E)-4-(2,2-dimethyl-6-methylidenecyclohexyl)but-3-en-2-one

49816-69-5
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13720-12-2
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References

alpha,2,2-trimethyl-6-methylenecyclohexanepropanol

13720-13-3
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13720-12-2
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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917-54-4
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$44.39/50ml

13720-12-2
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References

1000210-73-0
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13720-12-2
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References