![](/StructureFile/ChemBookStructure3/GIF/CB7182778.gif)
4-(2,4-DICHLORO-BENZYLOXY)-3-METHOXY-BENZALDEHYDE synthesis
- Product Name:4-(2,4-DICHLORO-BENZYLOXY)-3-METHOXY-BENZALDEHYDE
- CAS Number:342592-68-1
- Molecular formula:C15H12Cl2O3
- Molecular Weight:311.16
![2,4-Dichlorobenzyl chloride](/CAS/GIF/94-99-5.gif)
94-99-5
365 suppliers
$5.00/10g
![Vanillin](/CAS/GIF/121-33-5.gif)
121-33-5
1090 suppliers
$9.00/1g
![4-(2,4-DICHLORO-BENZYLOXY)-3-METHOXY-BENZALDEHYDE](/StructureFile/ChemBookStructure3/GIF/CB7182778.gif)
342592-68-1
23 suppliers
$57.50/250mg
Yield:342592-68-1 73%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 70; for 3 h;
Steps:
Method b:
General procedure: The aldehyde intermediate was synthesized using Cs2CO3 as base and DMF as solvent. Vanillin (500 mg, 3.289 mmol, 1 eq) and the corresponding halogenide (3.947 mmol, 1.2 eq) were dissolved in 15 ml DMF. The resulting suspension was heated under reflux for 2h at 70°C. The suspension was diluted with water and then extracted three times with ethyl acetate. Solvent was evaporated and the residue was recrystallized in methanol/water.
References:
Carrasco-Gomez, Roberto;Keppner-Witter, Sarah;Hieke, Martina;Lange, Lisa;Schneider, Gisbert;Schubert-Zsilavecz, Manfred;Proschak, Ewgenij;Sp?nkuch, Birgit [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 21,p. 5063 - 5069] Location in patent:supporting information