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78725-51-6

4-(2 4-DICHLOROPHENOXY)BENZALDEHYDE 97 synthesis

2synthesis methods
-

Yield:78725-51-6 77%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 60; for 18 h;

Steps:

13.1 Step 1: Synthesis of 4- (2,4-dichlorophenoxy) benzaldehyde

P-fluorobenzaldehyde (2.48g, 20.00mmol), 2,4-dichlorophenol (3.32g, 20.00mmol), potassium carbonate (11.00g, 80.00mmol), and N, N-dimethylformamide (30mL) Add it to a 250 mL single-necked flask, and react for 18 h in an oil bath at 60 ° C. Add ice water (200 mL) to the reaction solution, stir for 10 min to precipitate a solid, filter, and wash the cake with water (50 mL x 3)The title compound was obtained (yellow solid, 4.1 g, yield: 77%).

References:

CN110317200,2019,A Location in patent:Paragraph 0308-0311