![](/CAS/GIF/1171775-66-8.gif)
4-(2,4-DIFLUOROPHENOXY)PIPERIDINE HYDROCHLORIDE synthesis
- Product Name:4-(2,4-DIFLUOROPHENOXY)PIPERIDINE HYDROCHLORIDE
- CAS Number:1171775-66-8
- Molecular formula:C11H14ClF2NO
- Molecular Weight:249.6848
![1-Piperidinecarboxylic acid, 4-(2,4-difluorophenoxy)-, 1,1-dimethylethyl ester](/CAS/20200401/GIF/954226-82-5.gif)
954226-82-5
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![4-(2,4-DIFLUOROPHENOXY)PIPERIDINE HYDROCHLORIDE](/CAS/GIF/1171775-66-8.gif)
1171775-66-8
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$240.00/100mg
Yield:-
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane at 20;Inert atmosphere;
Steps:
23.2
A 4N-hydrochloric acid 1,4-dioxane solution (30 ml) was added to a 1,4-dioxane solution (30 ml) of t-butyl 4-(2,4-difluorophenoxy)piperidine-1-carboxylate (2.28 g, 7.28 mmol), under nitrogen stream, and the mixture was allowed to react at room temperature overnight. The reaction solution was concentrated to afford 4-(2,4-difluorophenoxy)piperidine hydrochloride (1.63 g) as a white solid.
References:
EP2258697,2010,A1 Location in patent:Page/Page column 43
![N-BOC-4-Hydroxypiperidine](/CAS/GIF/109384-19-2.gif)
109384-19-2
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![4-(2,4-DIFLUOROPHENOXY)PIPERIDINE HYDROCHLORIDE](/CAS/GIF/1171775-66-8.gif)
1171775-66-8
25 suppliers
$240.00/100mg
![2,4-Difluorophenol](/CAS/GIF/367-27-1.gif)
367-27-1
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$6.00/5g
![4-(2,4-DIFLUOROPHENOXY)PIPERIDINE HYDROCHLORIDE](/CAS/GIF/1171775-66-8.gif)
1171775-66-8
25 suppliers
$240.00/100mg