4-(2-BROMOETHOXY)BENZONITRILE synthesis
- Product Name:4-(2-BROMOETHOXY)BENZONITRILE
- CAS Number:37142-39-5
- Molecular formula:C9H8BrNO
- Molecular Weight:226.07
Yield:37142-39-5 53%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 100; for 5 h;
Steps:
30.1
A reaction mixture of 4-hydroxybenzonitri.le (1.19 g, 10 mmol), 1,2-dibromoethane (9.39 g, 50 mmol), and K2CO3 (4.14 g, 30 mmol) in DMF (20 mL) was stirred at 100 0C for 5 h and cooled to room temperature. To the reaction mixture was added ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The residue was purified by column chromatography to afford the 4-(2- bromoethoxy)benzonitrile (1.2 g, 53%).
References:
WO2007/89462,2007,A2 Location in patent:Page/Page column 33
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