4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine synthesis

Yield:60597-72-0 92%

Reaction Conditions:

in 1,4-dioxane at 60; for 1 h;

Steps:

3.3.5. Synthesis of 2-Chloro-N-Substitutedpyridinesulfonamides 10a-g. General Procedure E

General procedure: Secondary amine 9a-f (0.22 mol) was added, for 5 min at room temperature, to a stirred solution ofsulfonyl chloride 1a,b (21.2 g, 0.1 mol) in dry dioxane (100 mL). The reaction mixture was stirred at 60 °Cfor 1 h. After cooling, the reaction mixture was diluted with water (500 mL). The precipitate that formedwas filtered and recrystallized from i-propanol. Yields of 2-chloro-N-substitutedpyridinesulfonamides10a-g were 67-92%.

References:

Karpina, Veronika R.;Kovalenko, Svitlana S.;Kovalenko, Sergiy M.;Drushlyak, Oleksandr G.;Bunyatyan, Natalya D.;Georgiyants, Victoriya A.;Ivanov, Vladimir V.;Langer, Thierry;Maes, Louis [Molecules,2020,vol. 25,# 19,art. no. 4485]