![](/CAS/GIF/60597-72-0.gif)
4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine synthesis
- Product Name:4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine
- CAS Number:60597-72-0
- Molecular formula:C9H11ClN2O3S
- Molecular Weight:262.71
![Morpholine](/CAS/GIF/110-91-8.gif)
110-91-8
677 suppliers
$9.00/1g
![2-Chloropyridine-3-sulfonyl chloride](/CAS/GIF/6684-06-6.gif)
6684-06-6
135 suppliers
$20.00/1g
![4-[(2-Chloropyridin-3-yl)sulphonyl]morpholine](/CAS/GIF/60597-72-0.gif)
60597-72-0
31 suppliers
$424.00/1g
Yield:60597-72-0 92%
Reaction Conditions:
in 1,4-dioxane at 60; for 1 h;
Steps:
3.3.5. Synthesis of 2-Chloro-N-Substitutedpyridinesulfonamides 10a-g. General Procedure E
General procedure: Secondary amine 9a-f (0.22 mol) was added, for 5 min at room temperature, to a stirred solution ofsulfonyl chloride 1a,b (21.2 g, 0.1 mol) in dry dioxane (100 mL). The reaction mixture was stirred at 60 °Cfor 1 h. After cooling, the reaction mixture was diluted with water (500 mL). The precipitate that formedwas filtered and recrystallized from i-propanol. Yields of 2-chloro-N-substitutedpyridinesulfonamides10a-g were 67-92%.
References:
Karpina, Veronika R.;Kovalenko, Svitlana S.;Kovalenko, Sergiy M.;Drushlyak, Oleksandr G.;Bunyatyan, Natalya D.;Georgiyants, Victoriya A.;Ivanov, Vladimir V.;Langer, Thierry;Maes, Louis [Molecules,2020,vol. 25,# 19,art. no. 4485]