ChemicalBook CAS DataBase List 4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL

4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL synthesis

6synthesis methods

Product Name:4-[2-(CYCLOPROPYLMETHOXY)ETHYL]PHENOL
CAS Number:63659-16-5
Molecular formula:C12H16O2
Molecular Weight:192.25

1-(benzyloxy)-4-[2-(cyclopropylmethoxy)ethyl]benzene

63659-15-4
2 suppliers
inquiry

63659-16-5
68 suppliers
$125.00/25 mg

Yield:63659-16-5 86%

Reaction Conditions:

with hydrogen;nickel in methanol under 3361.55 Torr; for 5 h;Parr Shaker;

Steps:

VI
This example describes the preparation of 4-(2-cyclopropylmethoxyethyl)phenol of formula (9) The reported debenzylation procedure U.S. Pat. No. 4,348,783 using palladium charcoal was modified given as below. A solution of compound of formula (8), (12 g) in methanol (100 ml) was stirred in presence of Raney-Nickel (10 ml slurry) under H₂ pressure (Parr Shaker 65-psi pressure). After 5 h the reaction mixture was filtered through a pad of cellite and the filtrate was concentrated. The crude product was purified by silica gel chromatography using ethyl acetate and light petroleum ether (1:9) as an eluent to afford compound of formula (9), as an oil 7 g (86%).

References:

Council of Scientific and Industrial Research US2006/4109, 2006, A1 Location in patent:Page/Page column 3-5

FullText

61439-59-6 Synthesis