4-(2-FLUORO-PHENYL)-4-OXO-BUTYRIC ACID synthesis

Yield:90429-80-4 96%

Reaction Conditions:

with dihydrogen peroxide;C₂₈H₃₆F₆MnN₄O₆S₂;glacial acetic acid in lithium hydroxide monohydrate;acetonitrile at 20; for 1 h;chemoselective reaction;

References:

Zhou, Jimei;Jia, Minxian;Song, Menghui;Huang, Zhiliang;Steiner, Alexander;An, Qidong;Ma, Jianwei;Guo, Zhiyin;Zhang, Qianqian;Sun, Huaming;Robertson, Craig;Bacsa, John;Xiao, Jianliang;Li, Chaoqun [Angewandte Chemie - International Edition,2022,vol. 61,# 30,art. no. E202205983][Angew. Chem.,2022,vol. 134,# 30] Location in patent:supporting information