![](/CAS/GIF/769132-75-4.gif)
4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID synthesis
- Product Name:4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID
- CAS Number:769132-75-4
- Molecular formula:C10H13NO3
- Molecular Weight:195.22
![Benzoic acid, 4-[(2-hydroxyethyl)methylamino]-, ethyl ester](/CAS/20210305/GIF/149326-00-1.gif)
149326-00-1
0 suppliers
inquiry
![4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID](/CAS/GIF/769132-75-4.gif)
769132-75-4
16 suppliers
$60.00/100mg
Yield:769132-75-4 27%
Reaction Conditions:
Stage #1: ethyl 4-
Stage #2: with hydrogenchloride in water;
Steps:
44
Reference Example 44; 4- [(2-Hydroxyethyl)(methyl)amino]benzoic acid; To a solution (10 ml) of ethyl 4-[(2- hydroxyethyl)(methyl)amino]benzoate (500 mg, 2.24 mmol) in methanol was added 1M aqueous sodium hydroxide solution (10 ml), and the mixture was stirred at room temperature for 3 hrs. Water was added to the reaction mixture, and the mixture was washed with diethyl ether. 1M Hydrochloric acid (10 ml) was added, and the mixture was extracted with dichloromethane and concentrated under reduced pressure to give the title compound (119 mg, 27%) as a white solid. 1H-NMR (CDC13) 8: 3. 07 (3H, s) , 3. 56 (2H, t, J=6.0'Hz), 3.78 (2H, t, J=6.0 Hz), 3.8.4 (lH, s), 6.70 (2H, d, J=8.9 Hz), 7.90 (2H, d, J=8.9 Hz).
References:
WO2005/105802,2005,A1 Location in patent:Page/Page column 117-118
![Benzocaine](/CAS/GIF/94-09-7.gif)
94-09-7
765 suppliers
$5.00/50mg
![4-[(2-HYDROXY-ETHYL)-METHYL-AMINO]-BENZOIC ACID](/CAS/GIF/769132-75-4.gif)
769132-75-4
16 suppliers
$60.00/100mg