ChemicalBook CAS DataBase List 4-(2-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

4-(2-METHOXY-PHENYL)-THIAZOL-2-YLAMINE synthesis

5synthesis methods

Product Name:4-(2-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
CAS Number:93209-95-1
Molecular formula:C10H10N2OS
Molecular Weight:206.26

579-74-8 Synthesis

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93209-95-1
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Yield:93209-95-1 93%

Reaction Conditions:

with carbon tetrabromide;triethylamine in acetonitrile at 20; for 2 h;

Steps:

General procedure for the synthesis of 2-aminothiazoles 3

General procedure: To a mixture of ketone (0.5 mmol), thiourea (0.5 mmol), and triethylamine (0.5 mmol) in acetonitrile (3 mL) was added carbon tetrabromide (0.5 mmol) in a round bottom flask at room temperature and the reaction mixture was stirred for 2-6 h. After completion of the reaction (monitored by TLC), water (5 mL) was added and the mixture was extracted with EtOAc (3*5 mL). The combined organic phase was dried over MgSO4, filtered, and evaporated under reduced pressure to give the crude product. The resulting product was purified by silica gel column chromatography using a gradient mixture of hexane/ethyl acetate as eluent to afford an analytically pure sample of 3.

References:

Keshari, Twinkle;Kapoorr, Ritu;Yadav, Lal Dhar S. [Tetrahedron Letters,2015,vol. 56,# 41,p. 5623 - 5627] Location in patent:supporting information

31949-21-0 Synthesis