4-(2-METHYLIMIDAZOL-1-YLMETHYL)PHENYLAMINE synthesis
- Product Name:4-(2-METHYLIMIDAZOL-1-YLMETHYL)PHENYLAMINE
- CAS Number:772311-98-5
- Molecular formula:C11H13N3
- Molecular Weight:187.24
56643-86-8
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772311-98-5
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Yield:772311-98-5 86%
Reaction Conditions:
with iron;ammonium chloride in methanol;water at 60; for 2 h;
Steps:
1.5 Example 1.5 Preparation of Intermediate 3b
Take intermediate 2b (1.74g, 8.0mmol), iron powder (16.0mmol), saturated aq.NH4Cl in methanol, and react at 60 ° C for 2h. The reaction was completed by TLC. The iron powder was filtered off, methanol was distilled off under reduced pressure, ethyl acetate was extracted, and the organic layer was washed with dilute ammonia water. The organic layer was dried over anhydrous sodium sulfate, then the solvent was distilled off under reduced pressure, and the product was separated by column chromatography. The yield was 86%.
References:
CN111018842,2020,A Location in patent:Paragraph 0028; 0075-0076
100-11-8
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772311-98-5
35 suppliers
$40.00/1g