4-(2-PYRIDINYLMETHOXY)BENZALDEHYDE synthesis

5synthesis methods

Product Name:4-(2-PYRIDINYLMETHOXY)BENZALDEHYDE
CAS Number:57748-41-1
Molecular formula:C13H11NO2
Molecular Weight:213.23

4377-33-7 Synthesis

4377-33-7
102 suppliers
$90.00/250mg

123-08-0 Synthesis

123-08-0
892 suppliers
$5.00/10g

57748-41-1
26 suppliers
$45.00/50mg

Yield:57748-41-1 88%

Reaction Conditions:

Stage #1: 4-hydroxy-benzaldehydewith potassium carbonate in acetonitrile; for 0.5 h;
Stage #2: 2-chloromethylpyridine in acetonitrile; for 8 h;Reflux;

Steps:

4.2.7 General procedure for the synthesis of benzaldehydes 9a-13a, 9b-13b and 9c-13c

General procedure: The corresponding hydroxybenzaldehyde (1a-1c) was dissolved in dry acetonitrile (15-20mL) and K₂CO₃ (1.5 eq) was added. The reaction mixture was stirred for 30min and the appropriate halide (1 eq) was added and stirring was continued overnight at reflux temperature. The course of the reaction was monitored by TLC. After completion of the reaction, the solvent was evaporated under reduced pressure and the residue was purified by column chromatography.

References:

Kelly, John M.;Taylor, Martin C.;Baji?, Miroslav;Bokuli?, Ana;Jeli?, Dubravko;Ko?trun, Sanja;Krstulovi?, Luka;Popov, Andrea Bistrovi?;Rai?-Mali?, Silvana;Stojkovi?, Marijana Radi?;Zonji?, Iva [European Journal of Medicinal Chemistry,2020,vol. 207,art. no. 112802]

6959-47-3 Synthesis