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ChemicalBook CAS DataBase List 4-(2-THENOYL)PYRIDINE

4-(2-THENOYL)PYRIDINE synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

Stage #1:2-bromothiophene;pyridine-4-carbonitrile with n-butyllithium in diethyl ether;hexane at -78 - 0; for 0.5 h;
Stage #2: with hydrogenchloride in diethyl ether;hexane; pH=1 for 0.5 h;

References:

Jakobsen, Palle;Madsen, Peter;Andersen, HenrikSune [European Journal of Medicinal Chemistry,2003,vol. 38,# 4,p. 357 - 362]