4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRIC ACID synthesis
- Product Name:4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRIC ACID
- CAS Number:84313-94-0
- Molecular formula:C10H8F2O3
- Molecular Weight:214.17
108-30-5
614 suppliers
$5.00/25g
367-11-3
306 suppliers
$10.00/1g
84313-94-0
17 suppliers
$60.00/5mg
Yield:84313-94-0 77%
Reaction Conditions:
with aluminum (III) chloride at 40; for 16 h;Friedel-Crafts Acylation;
Steps:
1 Example 1: Preparation of 4-(3,4-difluorophenyl)-4-oxobutanoic acid (IIIa)
To a mixture of 1,2-difluorobenzene (I) (15 mL) and succinic anhydride (IIa) (4.0 g, 40.0 mmol) was slowly added AlCl3 (16.0 g, 120 mmol). The resulting reaction mixture was stirred at 40°C for 16 h, then it was poured to the mixture of 37% HCl (20 mL) and ice (50 g). After extraction with MeTHF (3 x 20 mL), combined organic layers are dried over MgSO4, and then concentrated to afford crude product, which was then recrystallized from toluene to give 6.6 g (77% yield) of title compound as white powder. Melting point 80°C; MS (ESI) m/z: 215 [MH]+.
References:
EP2628721,2013,A1 Location in patent:Paragraph 0029; 0045; 0046
348-61-8
391 suppliers
$6.00/5g
84313-94-0
17 suppliers
$60.00/5mg