4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE synthesis
- Product Name:4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE
- CAS Number:795310-52-0
- Molecular formula:C9H16N4
- Molecular Weight:180.25
![1-benzyl-4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine](/CAS/20200331/GIF/280111-37-7.gif)
280111-37-7
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795310-52-0
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Yield:795310-52-0 89.7%
Reaction Conditions:
with 10 wt% Pd(OH)2 on carbon;hydrogen at 40; under 2068.65 Torr; for 12 h;
Steps:
21E prepration of 4-(3,5-Dimethyl-[l,2,4]triazol-4-yl)-piperidine
Example 2 IE4-(3,5-Dimethyl-[l,2,4]triazol-4-yl)-piperidine Example 21D (0.234 g, 0.856 mmol), Pd(OH)2/C (100 mg) in EtOH (20 mL) was hydrogenation under under 40 psi of ? for 12 hours at 40 °C. TLC (MeOH :dichloromethane = 1 :8 ) indicated the reaction was complete, the mixture was filtered and the filtrate was concentrated in vacuum. The residue was dried to give Example 21E (140 mg, 89.7%).
References:
WO2013/10453,2013,A1 Location in patent:Page/Page column 112
50534-23-1
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795310-52-0
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795310-52-0
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