4-(3,5-Dinitrobenzoyl)morpholine synthesis

5synthesis methods

Product Name:4-(3,5-Dinitrobenzoyl)morpholine
CAS Number:133339-10-3
Molecular formula:C11H11N3O6
Molecular Weight:281.22

110-91-8 Synthesis

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99-34-3 Synthesis

99-34-3
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133339-10-3
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Yield:133339-10-3 63%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine;HATU in acetonitrile at 20;

Steps:

36.1 Step 1. (3,5-dinitrophenyl)morpholinylmethanone (intermediate 16)

Raw material 15 (424 mg, 2mmol), morpholine (0.174 ml), 2-(7-azabenzotriazolyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (912 mg, 2 . 4mmol) dissolved in acetonitrile (10 ml) in, by adding diisopropylethylamine (1.04 ml), stirring the mixture at room temperature for overnight. turns on lathe does, added 10% NaHCO₃solution (10 ml), dichloromethane extraction three times, combined with the phase, saturated salt water for washing again, drying, turns on lathe does, column chromatography separation to obtain the solid (355 mg, yield: 63%).

References:

CN105601573,2016,A Location in patent:Paragraph 0435; 0436; 0437; 0438

110-91-8 Synthesis

110-91-8
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$9.00/1g

99-33-2 Synthesis