4-(3-fluoro-benzyloxy)-benzaldehyde synthesis
- Product Name:4-(3-fluoro-benzyloxy)-benzaldehyde
- CAS Number:66742-57-2
- Molecular formula:C14H11FO2
- Molecular Weight:230.23
1000370-26-2
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66742-57-2
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Yield:66742-57-2 97.5%
Reaction Conditions:
with potassium carbonate;cetyltrimethylammonium bromide in toluene; for 7 h;Product distribution / selectivity;Heating / reflux;
Steps:
11.3
4-(3-Fluorobenzyloxy)benzaldehyde is prepared in 97.5% yield with a content of 3- (3-fluorobenzyl) -4- (3-fluorobenzyloxy)benzaldehyde (Via) of 0.45% by weight, determined by GC (see Example 24B), by reacting 4- hydroxybenzaldehyde (15.6g) with 3-fluorobenzyl methanesulfonate instead of 3-fluorobenzyl chloride according to the same procedure of Example 11. This product is further purified according to the procedure of the Example 11.1 to lower the content of impurity (Via) to 0.01 % by weight.
References:
WO2009/74478,2009,A1 Location in patent:Page/Page column 60
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66742-57-2
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66742-57-2
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123-08-0
905 suppliers
$5.00/10g
456-41-7
289 suppliers
$13.00/25g
66742-57-2
159 suppliers
$7.00/250mg
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905 suppliers
$5.00/10g
456-42-8
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1000370-24-0
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66742-57-2
159 suppliers
$7.00/250mg