ChemicalBook CAS DataBase List 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenol

4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenol synthesis

7synthesis methods

Product Name:4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenol
CAS Number:156824-51-0
Molecular formula:C8H5F3N2O
Molecular Weight:202.13

25458-45-1 Synthesis

25458-45-1
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4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenol

156824-51-0
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Yield:-

Steps:

Multi-step reaction with 6 steps
1: 1.) Mg / 1.) THF, 2.) THF
2: 98 percent / NH₂OH*HCl / ethanol; pyridine / 4 h / 60 °C
3: Et₃N, N,N-dimethylaminopyridine / CH₂Cl₂ / 0.5 h / Ambient temperature
4: NH₃ (liq.) / CH₂Cl₂ / 12 h / Ambient temperature
5: 85 percent / tert-butyl hypochlorite, Et₃N / 2-methyl-propan-2-ol; ethanol / 0.5 h / 0 °C
6: acetic acid, 1N aq. HCl / 12 h / Ambient temperature

References:

Hatanaka;Hashimoto;Nakayama;Kanaoka [Chemical and Pharmaceutical Bulletin,1994,vol. 42,# 4,p. 826 - 831]

3-(4-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine

891501-19-2
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156824-51-0
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References

Ethanone, 2,2,2-trifluoro-1-[4-(methoxymethoxy)phenyl]-

125680-78-6
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156824-51-0
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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156824-51-0
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References

1000210-73-0
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156824-51-0
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References