4(3H)-Quinazolinone, 2-(3-hydroxyphenyl)- synthesis
- Product Name:4(3H)-Quinazolinone, 2-(3-hydroxyphenyl)-
- CAS Number:911417-23-7
- Molecular formula:C14H10N2O2
- Molecular Weight:238.24
56071-04-6
20 suppliers
inquiry
911417-23-7
33 suppliers
inquiry
Yield:911417-23-7 100%
Reaction Conditions:
Stage #1: 2-(3-methoxyphenyl)quinazolin-4(3H)-onewith boron tribromide in dichloromethane at -78 - 20; for 4 h;
Stage #2: with methanol in dichloromethane at -78 - 20; for 0.5 h;
Steps:
3
To 2-(3-methoxyphenyl)quinazolin-4(3H)-one (11.6 g, 45.98 mmole) was added OfCH2Cl2 (120 mL) and the mixture was cooled to -78 0C. Then, a 1 M solution of BBr3 in CH2Cl2 (60 mL, 60.0 mmol) was added drop wise and the reaction was stirred at - 78 0C for 1 h and then ambient temperature for 3 h. The reaction was re-cooled to - 78 0C and cautiously quenched with MeOH (20 mL). The ice bath was removed and the system allowed to stir at ambient temperature for 0.5 h. The pH was adjusted to 7 with 10 % w/w NaHCO3 solution. The solid was filtered, washed with ether, dried and then azeotroped from toluene (3 X) and dried under high vacuum overnight to give 2-(3- hydroxyphenyl)quinazolin-4(3H)-one. (11. Og, mmol, 100%).
References:
WO2008/54599,2008,A2 Location in patent:Page/Page column 105
330657-87-9
12 suppliers
inquiry
911417-23-7
33 suppliers
inquiry
1711-05-3
170 suppliers
$8.00/1g
911417-23-7
33 suppliers
inquiry
67836-50-4
3 suppliers
inquiry
911417-23-7
33 suppliers
inquiry