4(3H)-Quinazolinone, 6,8-dimethoxy- synthesis
- Product Name:4(3H)-Quinazolinone, 6,8-dimethoxy-
- CAS Number:79263-01-7
- Molecular formula:C10H10N2O3
- Molecular Weight:206.2
Yield:79263-01-7 76%
Reaction Conditions:
with ammonium acetate in ethanol at 90; for 16 h;
Steps:
50.1 Step-1: Synthesis of 6,8-dimethoxyquinazolin-4(3H)-one:
A mixture of 2- amino-3,5-dimethoxybenzoic acid (0.25 g, 1.2 mmol, 1 eq), ammonium acetate (0.127 g, 1.5 mmol, 1.3 eq) and triethylorthoformate (0.33 mL, 1.9 mmol, 1.6 eq) in ethanol (5 mL) was allowed to stir at 90 °C for 16 h. Progress of reaction was monitored by TLC. Reaction mixture was cooled to RT, solid was filtered, washed with hexane and dried to afford 6,8- dimethoxyquinazolin-4(3H)-one (200 mg, 76%). LCMS: 207 [M+1]+
References:
WO2022/91048,2022,A1 Location in patent:Paragraph 417
79263-00-6
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