ChemicalBook CAS DataBase List 4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE

4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE synthesis

8synthesis methods

Product Name:4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE
CAS Number:91347-99-8
Molecular formula:C11H12BrN
Molecular Weight:238.12

tert-butyl 4-(4-bromophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

273727-44-9
13 suppliers
inquiry

4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE

91347-99-8
46 suppliers
$59.00/100mg

Yield:91347-99-8 88 %

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;Inert atmosphere;

Steps:

9.2 Step 2: 4-(4-bromophenyl) - 1, 2, 3, 6-tetrahydropyridine

Trifluoroacetic acid (1.250 ml, 16.32 mmol)was added to solution of tert-butyl4-(4-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate (1.38 g, 4.08 mmol) in CH2CI2 (10ml) under argon at RT. The reaction mixture was stirred at RT for 1 h. Complete conversion to the desired product was observed by LCMS. The mixture was concentrated and the residue was dissolved in MeOH (20 mL), passed through a 5 G porapak cation exchange cartridge and the eluant was removed to afford the product as a beige solid (854 mg, 88%). LCMS: [M + H]+ = 240.36.

References:

WO2022/226665,2022,A1 Location in patent:Paragraph 0338; 0339

163209-96-9 Synthesis