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4-(4-BROMO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER synthesis

5synthesis methods
16532-79-9 Synthesis
4-Bromophenylacetonitrile

16532-79-9
333 suppliers
$6.00/5g

105-36-2 Synthesis
Ethyl bromoacetate

105-36-2
348 suppliers
$5.00/5G

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Yield:160010-18-4 90%

Reaction Conditions:

Stage #1: ethyl bromoacetatewith iodine;zinc in tetrahydrofuran; for 1 h;Reflux;
Stage #2: 4-Bromophenylacetonitrile in tetrahydrofuran; for 0.5 h;Reflux;

References:

Hornum, Mick;Mulberg, Mads W.;Szomek, Maria;Reinholdt, Peter;Brewer, Jonathan R.;Wüstner, Daniel;Kongsted, Jacob;Nielsen, Poul [Journal of Organic Chemistry,2021,vol. 86,# 2,p. 1471 - 1488]

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